ARPA-H funds research proposals from small businesses
Agency supports proposals for innovative research and development from small businesses
The Advanced Research Projects Agency for Health (ARPA-H) is seeking proposals from small businesses with the expertise to conduct innovative research and development to contribute toward the agency’s mission.
With a scope spanning the molecular to the societal, ARPA-H seeks Small Business Innovation Research (SBIR) proposals that aim to rapidly achieve better health outcomes across patient populations, communities, disease, and health conditions. Awardees will develop groundbreaking new ways to tackle health-related challenges through high-potential, high-impact biomedical and health research.
The application deadline is now closed.
Prior SBIR awards
ARPA-H expects awardees to use innovative approaches to enable revolutionary advances in science, technology, or systems. Awards made from the SBIR solicitation are generally in the form of contracts. Exact award amounts depend on meeting aggressive milestones, typical to the ARPA-H process.
ARPA-H is pleased to announce the following SBIR awardees:
Design Integration and Testing of a Low-Cost Disposable Remotely Controlled Microneedle Transdermal Drug Delivery Device
The project plans to develop Digital SatioRx, a very low cost remotely controllable disposable microneedle transdermal drug delivery device able to deliver any liquid FDA-approved transdermal drug. Digital SatioRx's telemedicine-enabled (EHR-integrated), remotely activated, disposable design and unique delivery system will minimize infection risk and ensure administration of a reproducible drug dose to any patient in seconds. It will allow providers to ensure compliance while reducing costs and inconvenience for patients. Design features from other Satio telemedicine devices and manually operated transdermal delivery devices will guide final design.
A Smart AI-based Digital Health Framework for Enhancing Pediatric Wellness
The primary purpose of the project is to build preliminary AI algorithms to detect Ear Nose Throat (ENT) and respiratory (asthma) issues in a pediatric rural population with the intention of facilitating telehealth diagnosis and treatment, and minimizing burdens related to accessing health care in rural areas.
Real-time Functional Fluorescence Nerve Imaging for Surgery
This project plans to synthesize and characterize novel nerve-specific fluorescence guided surgery (FGS) contrast agents to select a bright, water-soluble lead compound for clinical translation with optimal nerve visualization, functional assessment performance, and clinically relevant pharmacology and toxicology (pharm/tox) profiles for follow-on Investigational New Drug-enabling studies and first-in-human trials.
Translation of Novel Biliary Tract-specific Contrast Agent to Mediate Successful Image-guided Hepatobiliary Interventions
The project aims to advance the development of BL-760, a near-infrared contrast agent designed for clear intraoperative identification of bile ducts. This novel dye addresses the significant medical issue of bile duct injury during hepatobiliary surgeries (e.g., cholecystectomy, hepatectomy), impacting over 1 million patients annually. The project plans to produce BL-760 with high quality standards (GMP) and to conduct rigorous safety tests in a controlled lab environment (GLP), at the allow for Investigational New Drug (IND)-enabling studies to test the dye in humans. The project outcome will improve patient outcomes and set a new standard of care in the field of hepatobiliary surgery.
Digital Assessment of Children’s Conditions Using Artificial Intelligence (“DACCS AI”)
This project explores applying artificial intelligence (AI), transfer learning, and assessment of mobile phone images of pediatric throat, otoscopy ear, and skin conditions to help enable remote pediatric care of colds, sore throats, ear infections and other diseases.
StrepApp: Deep Learning to Diagnose Streptococcal Pharyngitis
This Phase II project is for the advancement of diagnostic capabilities for detecting Group A Streptococcus pharyngitis (GAS). The goals under the contract include a comprehensive and diverse database, multiple trained and optimized deep learning models deployable on a mobile device, FDA clearance for the algorithms, and the validation of the app's performance through clinical research. These achievements will establish the foundation for a reliable, accurate, and user-friendly diagnostic tool that can effectively detect GAS pharyngitis in children.
Highly Miniaturized and Portable MALDI-2 Based Imaging Mass Spectrometry for Point-of-Care Clinical Diagnostics
This project plans to design, optimize, test, and deliver two fully functional miniature, portable MALDI-2 imaging mass spectrometer (IMS) prototype systems capable of high-resolution imaging mass spectrometry. The miniaturized IMS will support a disruptive technology as a portable point-of-care clinical diagnostic.
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