The overarching goal of the CT-NEURO program is to develop strategies for targeting therapeutic immune cells to the central nervous system using biological logic gates. Three specific objectives include 1) development of an immune cell-based, disease-agnostic platform that targets therapeutic payload to the brain, 2) demonstrating that this platform can be expanded to generate engineered cells to selectively target other organs and tissue types, and 3) employing this platform to deliver therapeutic payloads to treat diverse neurological conditions such as brain tumors, neuroinflammatory diseases, demyelination, and neurodegeneration.