This project aims to develop personalized radiopharmaceuticals for PET imaging-based diagnosis and targeted treatment for multiple cancers. This will be achieved through the computer-aided design of custom ligands targeted to cancer cell membrane proteins and through the development of two table-top devices. The first device will be capable of producing very small doses of radiopharmaceuticals on-site at the patient clinic through a single push of a button. The second device will permit parallelized labeling under varying reaction conditions and using varying ligands/radioisotopes, enabling fast-track development of diagnostic and treatment radiolabeled compounds. The resulting targeted imaging and treatment will enable personalized diagnostic PET imaging and radiotherapy, the latter of which could easily be extended to resource-limited clinics and hospitals via a low-dose micro-radiolabeling system developed through the project.