The proposed Real-time Analysis and Discovery in Integrated And Networked Technologies (RADIANT) toolkit seeks to develop an extensible, federated framework for rapid exchange of multimodal clinical and research data on behalf of accelerated discovery and patient impact. The development activities pair software-enabled national infrastructure for data integration and interoperability with leading-edge portals and cloud platform deployments. Together, the RADIANT toolkit seeks to revolutionize current practices by enabling a new research care framework for real-time discovery and translational impact with children diagnosed with brain tumors as a driver use case. Coordination and implementation of initial RADIANT deployments will leverage a network of more than 35 partnered health care systems and participating patient families within the Children’s Brain Tumor Network (CBTN) and the Pediatric Neuro-Oncology Consortium (PNOC).