This project aims to create Oncology Learning Health Systems among health systems of all sizes and at any location. The overall scope of the University of North Carolina (UNC)-based center is to bring together structured and unstructured electronic health record (EHR)-derived data, insurance claims, and geographic data to rapidly identify cases and improve care quality via access to cutting edge clinical advances for cancer. The Cancer Identification and Precision Oncology Center (CIPOC) will facilitate an Oncology Health Learning System, through rapid, real-time identification and accurate characterization of newly diagnosed cancer cases for surveillance, patient recruitment, optimization of patient care, and largescale population research, providing equitable access to precision medicine.