Traumatic tissue injuries can happen unexpectedly and lead to life-threatening conditions. Despite advancements in wound care, millions of Americans lack immediate access to specialized medical facilities, increasing the risk of chronic wounds or death. Aging populations and individuals with underlying health conditions like diabetes and obesity are at greater risk of developing chronic wounds that fail to properly heal. The Tissue Preservation under Stress project seeks to develop cutting-edge technologies aimed at preserving the health and function of biological tissues under urgent stress or injury conditions. These therapies have the potential to significantly improve health care access for all Americans, especially in trauma care in under-resourced and rural communities. The TPS effort is a two-year focused effort on advanced development to translate these technologies toward clinical trials.