The Cyber Health Intelligence: Sensing and Self-Healing Cyber Vulnerabilities in Healthcare Ecosystems project will extend a previously DoE-funded framework - Common Weakness Enumerations (CWE) - into the healthcare sector. This technology, applied to the full ecosystem of connected things in healthcare and combined with novel orchestration and machine learning capabilities will dramatically improve cyber defenses. MD Anderson will achieve this by combining a) the digital ecosystem of healthcare at MD Anderson, b) a proven approach using machine learning technologies to enumerate and characterize cyber vulnerabilities and corresponding weaknesses, and c) an approach to facilitate weakness prioritization and mitigation through interactive prompting.