The AFC-HEALTH project will leverage the PRIME registry, the largest primary care data registry in the U.S., which contains Electronic Health Record (EHR) data on 8 million patients. The project will establish data partnerships to expand the registry by 50 percent, building an enriched dataset to help elucidate the social determinants of health and causal drivers of disease. By addressing critical barriers in data collection and utilization, the project will enable large-scale evaluation of the health effects of environmental, social, and educational policies. This will help enable the creation, implementation, and monitoring of evidence-based, equitable, and pragmatic primary care interventions. The use of responsible AI in healthcare will also be enhanced.