This project will develop technology for continuous, real-world monitoring of blood pressure, a key vital sign for assessing cardiovascular health. The proposed technology will improve accuracy, efficiency, and accessibility to enable individuals and their clinicians to monitor blood pressure (BP) “beat-to-beat,” facilitating diagnosis and management of cardiovascular diseases, which are the leading cause of mortality in the United States and globally. Moreover, digital access to unprecedented continuous data will generate novel insights for disease prediction and improved care for cardiovascular and circulatory conditions. To date, an accurate and continuous blood pressure monitor in a wearable form factor for consumer use is not available. The CLINAC-BP solution leverages technology to measure changes in the arteries’ electrical properties as the heart beats that can then be converted into blood pressure values. This interdisciplinary team has designed an approach that will integrate advances in radio frequency monitoring technology, hardware, and AI/software to develop a wearable and connected continuous blood pressure monitor for clinical accuracy as the user goes about daily life, at home, at work, and in the community.