The MIGHTY project aims to improve healthcare outcomes for all Americans in an era of rising antibiotic resistance, a significant threat to public health. MIGHTY will address the limitations of current therapeutic treatments by focusing on the human microbiome's role in health and disease. While antibiotics are often vital to kill harmful bacteria, they can also disrupt beneficial microbes. Phages are a class of viruses that only infect bacteria and offer an opportunity for more precise targeting of specific bacteria of interest. MIGHTY will harness the power of phages to alter the microbiome composition in favor of healthy outcomes. These phages will be provided in chewing gum or lozenges for initial targeting of the oral microbiome, particularly focusing on communities with high rates of oral disease. The MIGHTY project has the potential to revolutionize healthcare by using phages to maintain a balance between healthy and unhealthy bacteria, influencing every organ in the human body throughout our lifespan.