What if women’s long-term health could be protected by eliminating the adverse effects of menopause?

Menopause, defined as the cessation of ovarian function, is a universal experience of all healthy women later in life. Because of its significant health impacts, menopause is associated with increased risk of major morbidities, including cancer, dementia, and cardiovascular disease. We propose constructing a cell-therapy implant made of human induced pluripotent stem cell-derived ovarian tissue and a supportive hydrogel matrix, which, when implanted in the body, will replace deficient ovarian function, restore normal hormonal processes, manage menopause-associated symptoms, and minimize the adverse health outcomes related to menopause.

Topic 2: Prioritizing Ovarian Health