Sophrosyne Biosciences, Inc. together with their partners aim to develop a revolutionary therapeutic to restore lost neocortical function in patients with permanent brain damage from stroke, traumatic brain injury, and neurodegeneration. The team will develop precursor tissue grafts that will mimic normal brain development to generate new, normally structured tissue that integrates with the adult brain, focusing initially on focal motor cortex stroke. The program aims for validated precursor tissue, reproducible graft survival, and FDA pre-IND engagement, providing a foundation for future regenerative neuroscience advances.