This project adds multimodal, objective measurements to clinical trials and real-world clinical practice to identify real-time signs of response to multiple treatments (e.g., ibogaine, psilocybin, neuromodulation). Using brain activity, wearable and sleep data, mental health questionnaires, and social activity measures, the project will study Veterans receiving several different therapies to find biomarkers that can predict both rapid improvement and durability of effects. Data collected under this award will be deidentified and housed in the ARPA-H EVIDENT Data Repository.