The team will build a scalable platform to map how intrinsically disordered region (IDR) sequence and biological context shape protein behavior across both a broad library of heterogeneous proteins and a depth of variants of a smaller group of aggregation-prone disease proteins. The team will leverage their computational platform to enable earlier detection and intervention in Alzheimer’s disease and other tauopathies (neurodegenerative disorders caused by the abnormal buildup of tau aggregates in the nervous system) and Ewing sarcoma, a rare and aggressive pediatric cancer that forms in bones or surrounding soft tissue.