Mito-IDR MAPS: Mitochondrial Aggregation Pathways in Stress-regulated neurodegeneration
The team will combine large-scale computational modeling with high-throughput cellular and animal studies to explore a novel hypothesis that stress-regulated IDRs enter mitochondria and contribute to neurodegenerative disease. The work builds on the established role for mitochondria in neurodegenerative disease and facilitating IDR misfolding and aggregation under cellular stress.