IMPEDE: Instruct & Modulate Protein Ensembles for Disease Evasion
The team will develop a first-in-class closed-loop computational-experimental pipeline to map the context-dependent IDR grammar. The work will first combine sequence to structure, function, condensation, aggregation, and binding partners; then refine the IDR atlas to design indicators and modulators of early protein aggregation in Alzheimer’s disease and idiopathic pulmonary fibrosis (a rare, uncurable chronic disease of the lung); and then move to preclinical studies to advance and validate candidates.