Anecdotal reports and early research suggest ibogaine and other neuroplastogen compounds may have promising effects on mental illnesses, such as post-traumatic stress disorder and opioid use disorder. However, little clinical research data is available to inform further research and clinical use of ibogaine. This project seeks to rapidly acquire high-fidelity clinical data to evaluate the safety, dosing, efficacy, and durability of ibogaine in populations with mental and behavioral health disorders who may benefit from innovative treatments, with an emphasis on U.S. Veterans.