REST Frequently Asked Questions (FAQs)

Per ISO Section 4.1, ARPA-H must prioritize awards to entities that will conduct the funded work in the United States. Non-domestic performers are encouraged to collaborate with a domestic entity. ARPA-H will not make awards to entities organized under the laws of a covered foreign country per 42 U.S.C. 290c(n)(1)(D).

Per ISO Section 4.1, Federally Funded Research and Development Centers (FFRDCs) and government entities, including federal employees, are not permitted to respond to this ISO as a prime or sub-performer. A Department of Veterans Affairs (VA)-affiliated investigator may submit a Solution Summary as either a non-profit employee or as a university employee.

Eligibility requirements are provided in ISO Section 4.1.

Per ISO Section 2.3.3, efforts focused solely on lifestyle or behavioral interventions, pharmacologic treatment, non-personalized interventions, or interventions that do not credibly use objective physiological measurements to adapt treatment to the user’s sleep state or physiology are out of scope. 

Per ISO Section 2.3.3, efforts focused solely on lifestyle or behavioral interventions, pharmacologic treatment, non-personalized interventions, or interventions that do not credibly use objective physiological measurements to adapt treatment to the user’s sleep state or physiology are out of scope.

Per ISO Sections 1.1, 2.1.1, and 2.1.2, REST is focused on home-based systems.

Per ISO Section 2.1.1, TA1 approaches may focus on during-sleep measurements, multi-night measurements, or broader 24-hour characterization of sleep and arousal as interdependent systems, provided the proposer explains how the approach supports REST objectives and stated program metrics.

Per ISO Section 2.1.2, strong TA2 proposals will deliver intervention during sleep, but alternative approaches that are responsive to individual sleep physiology will also be considered.

Per ISO Sections 3.2 and 3.3, this program requires human subjects research to meet success metrics and milestones.

Per ISO Section 2.1.1, proposed methods may also incorporate proposer-generated retrospective or prospective data collection and modeling efforts.

Per ISO Section 2.1.2, systems may comprise multiple coordinated devices rather than a single unified platform.

Per ISO Section 2.1.1, proposed methods may also incorporate proposer-generated retrospective or prospective data collection and modeling efforts.

Per ISO Section 1.1, proposers may either (1) submit one proposal to one of the two Technical Areas, OR (2) submit one proposal that addresses both Technical Areas as an integrated approach.

This program ISO does not specify funding range. Awards are anticipated in Spring 2027. Proposers should propose a budget that is appropriate and well justified for their approach and apply applicable HHS salary cap limitations.

Per ISO Sections 2.1.1, ARPA-H anticipates that proposers will secure industry cost share that increases as the work matures toward translation and commercialization. Proposers should describe a credible cost share strategy commensurate with the maturity and transition trajectory of the proposed technology, including anticipated source(s) of cost share, when such support is expected to become available (in terms of timing and/or milestones accomplished), and how the proposed cost share approach will support commercialization and long-term sustainability. Cost share is not required to be uniform across all team members. 

Lightening Talk presenters do not need to attend the entire Proposers' Day. However, Lightening Talks are not guaranteed, and presenters must be in-person to provide their talk.

Lightening Talks are not guaranteed, and presenters must be in-person to provide their talk.

Prospective performers are encouraged to use the Teaming Profiles page to share their capabilities and identify potential partners.