ARPA-H is developing methods to objectively, quantitatively, and longitudinally measure pain across a variety of chronic conditions. These methods seek to enable clinicians to evaluate disease evolution and to determine how well a woman’s course of treatment is addressing their pain. The pain measurement methods aim to be simple, inexpensive, and deployable in a range of settings. Accurate identification of the location of the pain generator and accurately distinguishing between different pain types are key parts of this work.