ARPA-H is working to revolutionize methods for data generation, analysis, and application in women’s health. This topic is advancing cutting-edge research, novel technologies, business models to sustain investment, and interdisciplinary approaches to forge strategies that address women’s health challenges. This topic is dedicated to reshaping women’s health research into a more comprehensive and forward-thinking endeavor, ensuring significant improvements in global health outcomes. If successful, these concepts will change the conversation and the practice of how we engage women’s health day-to-day.